Skip to main content

Advertisement

Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Table 1 Comparison of the siRNA_profile program and five other siRNA design programs

From: Analysis by siRNA_profile program displays novel thermodynamic characteristics of highly functional siRNA molecules

  siRNA_profile Deqor Ambion siDesign EMBOSS SiDirect
Number of hits 6 (4) 4(1) 3(0) 2(2) 6(4) 9(7)
Average GE%* 10.4 14.8 21.1 13.0 21.6 14.8
Median%* 10.2 13.1 26.9 13.0 16.1 14.9
Minimum GE%* 5.4 10.3 8.1 12.6 6.7 5.8
Maximum GE%* 15.1 22.8 28.3 13.3 54.1 32.2
  1. 197 nt human CyclophilinB sequence and data of known siRNA efficacies [8] were used for siRNA design program comparison. Number of hits that were not selected by any of five other programs is shown in brackets (). * Gene expression (GE) % of the baseline