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Table 1 Comparison of the siRNA_profile program and five other siRNA design programs

From: Analysis by siRNA_profile program displays novel thermodynamic characteristics of highly functional siRNA molecules

 

siRNA_profile

Deqor

Ambion

siDesign

EMBOSS

SiDirect

Number of hits

6 (4)

4(1)

3(0)

2(2)

6(4)

9(7)

Average GE%*

10.4

14.8

21.1

13.0

21.6

14.8

Median%*

10.2

13.1

26.9

13.0

16.1

14.9

Minimum GE%*

5.4

10.3

8.1

12.6

6.7

5.8

Maximum GE%*

15.1

22.8

28.3

13.3

54.1

32.2

  1. 197 nt human CyclophilinB sequence and data of known siRNA efficacies [8] were used for siRNA design program comparison. Number of hits that were not selected by any of five other programs is shown in brackets (). * Gene expression (GE) % of the baseline
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Source Code for Biology and Medicine

ISSN: 1751-0473