Probe_Statistics.txt: A table of results for regression of gene expression on the primary variable of interest before and after correcting for surrogate variables. This file includes the following columns (fields) for each gene/probesets/probes:

[pre-sva] calculations:

Coefficient unadjusted: linear regression coefficient from the fitted model before sva adjustment.

Fold change: up or down regulated (unadjusted), log2 ratio of mean expression of Group1 (e.g., "cases") vs. Group2 (e.g., "controls") from the fitted model before sva adjustment.

p_unadjusted: p-value for the test of significance comparing the mean expression levels between groups (e.g., Group1 or “cases” vs. Group2 or “controls”) for all genes/probesets/probes from the fitted model before sva adjustment.

[post-sva] calculations:

surrogate variables included as "covariates" in the linear regression model of gene expression on the primary variable of interest:

Coefficient after sva adjusted.

Fold change: up or down regulated after adjustment with sva

p_adjusted: p-value for the test of significance after sva adjustment