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Fig. 4 | Source Code for Biology and Medicine

Fig. 4

From: SOV_refine: A further refined definition of segment overlap score and its significance for protein structure similarity

Fig. 4

Top three plots: the relative frequency (i.e., conditional probabilities) of Q3, SOV’99, and SOV_refine for three-state secondary structure for protein pairs from Top8000 having the same and different CATH folds. For example, red lines indicate conditional probability \( P\left({SOV}_{-} refine\left|\overline{F}\right.\right) \) of SOV_refine score when the two proteins are in different CATH fold families whereas the blue lines indicate P(SOVrefine|F), which is the conditional probability of SOV_refine when the two proteins are in the same CATH fold family. Bottom three plots: posterior probability of proteins with a given score of Q3, SOV’99, and SOV_refine for three-state secondary structure when two proteins are in the same and different CATH folds. For example, the posterior probability of two proteins to have the same fold given a specific SOV_refine score is represented by P(F|SOVrefine), whereas \( P\left(\left.\overline{F}\right|{SOV}_{-} refine\right) \) for not having the same fold. Red lines indicate not having the same fold; and blue lines indicate having the same fold. The point when the two lines with different colors intersect is the score threshold, above which we think two proteins are having the same fold

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