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Table 1 Rules employed by a human expert to score the relevance of genes against the topic “DNA repair” using manual inspection of evidence from the Entrez Gene database

From: Annokey: an annotation tool based on key term search of the NCBI Entrez Gene database

Score Definition
2 Is most likely relevant to DNA repair or DNA damage response, supported by biochemical evidence of involvement in DNA damage response affecting DNA repair.
1 Is possibly involved in DNA repair or DNA damage response e.g., DNA repair protein binding partners without necessarily evidence of involvement in DNA repair, altered regulation in response to DNA damage or DNA damaging treatments but without direct evidence of a role in DNA repair.
0 Has no discernable involvement in DNA repair or DNA damage response and the key term match appears off-target e.g., refers to another gene mentioned in the same text as the test gene.