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Table 2 Quantitative comparison of volumetric segmentation accuracy between two manual observers (O 1 ,O 2 ), CELLPROFILER and CELLSEGM

From: CellSegm - a MATLAB toolbox for high-throughput 3D cell segmentation

Comparison/Coefficient C 1 C 2 C 3 C 1,n C 2,n C 3,n
O1-CellSegm 0.6772 0.7701 0.7302 0.8534 0.9187 0.7685
O2-CellSegm 0.7080 0.7690 0.7992 0.8842 0.9176 0.8375
O1-CellProfiler 0.1161 0.2961 0.1439 0.2923 0.4447 0.1822
O2-CellProfiler 0.1238 0.3060 0.1608 0.3000 0.4546 0.1991
O1-O2 0.8238 0.8514 0.9617 1.0000 1.0000 1.0000
  1. The columns are the evaluation coefficients C i , i = 1, 2, 3, as described in (1) and (2). The normalized evaluation coefficients Ci,n are also presented, arising after subtracting the inter-observer variability from C i . CELLSEGM has considerably higher success rates than CELLPROFILER.