Figure 5

Connection between Alzheimer’s disease and ubiquitin-mediated proteolysis. Differential gene expression levels from the posterior cingulate cortex region were overlaid on the Alzheimer’s disease (yellow) and ubiquitin-mediated proteolysis (blue) pathways. The region of the pathways that are directly and indirectly connected to each other is framed and also shown enlarged in the figure. The size of a node (representing a gene) represents the extent of differential gene expression between patients with the disease vs. controls. Although there are no common genes between these two pathways, 112 edges were observed that connected nodes (genes) between the two pathways (highlighted in red) based on inter-pathway connectivity derived from the pooled pathway. Several of these edges connect differentially expressed genes in these pathways, analogous to scenario (C) in Figure2.