Figure 1

Schematic representation of PathNet analysis. The direct evidence pertaining to differential gene expression is detected via microarray analysis while the indirect evidence of a gene is calculated from the direct evidences of its neighbors in the pathway. The direct and indirect evidences are combined, and the combined evidence is used to identify pathway enrichments via a hypergeometric test. The combined input of microarray data and pathway information yields a final pathway enrichment list that can be associated with the different test conditions in the samples.